[Para-aminosalicylic acid in the treatment of pulmonary tuberculosis].
نویسندگان
چکیده
This study was an attempt to determine whether the administration of large doses of para-aminosalicylic acid, 18 to 24 grams a day, was feasible and advantageous in the treatment of pulmonary tuberculosis. Patients for this study were not especially selected. Each one for whom antibacterial therapy was indicated and who had an odd hospital register number, between May 24, 1950 and January 1, 1951, was placed on 24 grams of PAS daily. In addition, six whose sputa showed organisms definitely resistant to streptomycin were added to the study. This made a total of 28 who were started on the proposed therapy. In six of the patients, collapse measures were added sometime during the course of treatment. The 28 included 22 with far-advanced and six with moderately advanced pulmonary tuberculosis. All had progressive, or at least stationary lesions. Seventeen were white and 11 were negro. All were males, 12 of whom were in the third decade of life, nine In the fourth decade, two in the fifth, four in the sixth and one In the seventh. All had positive sputum, on concentration, at the beginning of therapy. PAS was given in the form of sodium salt, prepared in our pharmacy according to the method described by Lyght.’ The equivalent of 6 grams of PAS was administered four times daily with food for a proposed period of 120 days. Of the 28 begun on 24 grams of PAS, only 12 (42.8 per cent) completed the course of 120 days. However, six others were able to complete the course after the daily dose was reduced to 18 grams. This makes a total of 18 (64.2 per cent) who were able to tolerate high doses of PAS for 120 days. Almost all developed some symptom of drug toxicity, mainly anorexia, vomiting, or
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ورودعنوان ژورنال:
- Minerva medica
دوره 40 62 Pt 2 شماره
صفحات -
تاریخ انتشار 1949